Antisynthetase syndrome

Summary: Antisynthetase syndrome is a chronic autoimmune condition that affects the muscles and various other parts of the body. The signs and symptoms can vary but may include muscle inflammation (myositis), polyarthritis (inflammation of many joints), interstitial lung disease, thickening ...1

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Symptoms of Antisynthetase syndrome

Symptoms: The signs and symptoms of antisynthetase syndrome vary but may include:[5, 1][2]

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Causes of Antisynthetase syndrome

Cause: The exact underlying cause of antisynthetase syndrome is currently unknown. However, it is considered an autoimmune disease. Autoimmune disorders occur when the body's immune system attacks and destroys healthy body tissue by mistake. In antisynthetase syndrome, specifically, the production ...2

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Diagnosis of Antisynthetase syndrome

Diagnosis: A diagnosis of antisynthetase syndrome is often suspected based on the presence of characteristic signs and symptoms once other conditions that cause similar features have been ruled out. Additional testing can then be ordered to confirm the diagnosis, determine ...3

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Treatments: Antisynthetase syndrome

Treatment: Corticosteroids are typically the first-line of treatment and may be required for several months or years. These medications are often given orally; however, in severe cases, intravenous methylprednisolone may be prescribe initially. Immunosuppressive medications may also be recommended ...4

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Names and Terminology

Related Diseases: The following diseases are related to Antisynthetase syndrome. If you have a question about any of these diseases, you can contact GARD.

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  1. Source: GARD (NIH): diseases/ 735/ antisynthetase-syndrome
  2. ibid.
  3. ibid.
  4. ibid.

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