Prognosis and Outlook for Antisynthetase syndrome

Prognosis for Antisynthetase syndrome


The long-term outlook (prognosis) for people with antisynthetase syndrome varies based on the severity of the condition and the signs and symptoms present. Although the condition is considered chronic and often requires long-term treatment, those with muscle involvement as the only symptom are generally very responsive to treatment with corticosteroids and/or immunosuppressive medications. When the lungs are affected, the severity and type of lung condition generally determines the prognosis.[1, 2][3] For example, patients with a progressive course of interstitial lung disease generally have a worse prognosis than those with a nonprogressive course, because respiratory failure is the main cause of death. However, in most cases the interstitial lung disease is nonprogressive.[7]

Older age at onset (greater than 60 years), severity and extension of lung disease, delay in diagnosis and treatment, presence of malignancy, and a negative Jo1 antibody test (Jo1 is the most frequent antibody in ASS) are all associated with a worse prognosis.[1, 3][8]

Last updated: 5/26/2016

Source: GARD (NIH)1

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  1. Source: GARD (NIH): diseases/ 735/ antisynthetase-syndrome

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