Autoimmune Lymphoproliferative Syndrome

Autoimmune Lymphoproliferative Syndrome (ALPS): Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of the immune system that affects both children and adults. In ALPS, unusually high numbers of white blood cells called lymphocytes accumulate in the lymph nodes, liver ...1

... More on Autoimmune Lymphoproliferative Syndrome »

   •   •   •

Back to: « Lymphoproliferative Syndrome

Symptoms of Autoimmune Lymphoproliferative Syndrome

In ALPS, unusually high numbers of white blood cells called lymphocytes accumulate in the lymph nodes, liver, and spleen, which can lead to enlargement of these organs. ALPS can cause numerous autoimmune problems such as anemia (low count of red ...2

... More Symptoms of Autoimmune Lymphoproliferative Syndrome »

Complications of Autoimmune Lymphoproliferative Syndrome

In ALPS, unusually high numbers of lymphocytes accumulate in the lymph nodes, liver, and spleen, causing these organs to enlarge. ALPS can cause anemia and reduce the number of pathogen-fighting neutrophils and clot-forming platelets in the blood, which ...3

... More on Complications of Autoimmune Lymphoproliferative Syndrome »

Causes of Autoimmune Lymphoproliferative Syndrome

Autoimmune Lymphoproliferative Syndrome (ALPS) Causes: Genetics Most cases of ALPS are caused by mutations in the FAS gene. The FAS gene produces a receptor that, when activated, leads to programmed cell death, or apoptosis. This is an important part of ...4

... More Causes of Autoimmune Lymphoproliferative Syndrome »

Causes List for Autoimmune Lymphoproliferative Syndrome

Some possible causes of Autoimmune Lymphoproliferative Syndrome or similar disorders may include:5

... Full Causes List for Autoimmune Lymphoproliferative Syndrome »

Types of Autoimmune Lymphoproliferative Syndrome

The most common form of ALPS, ALPS-FAS, is caused by mutations in the FAS gene. Not everyone with FAS mutations develops ALPS. Of the 415 people with FAS mutations evaluated at NIH since 1993, only 240—less than 60 ...6

... More Types of Autoimmune Lymphoproliferative Syndrome »

Diagnosis of Autoimmune Lymphoproliferative Syndrome

Diagnosis: The diagnosis of ALPS is based on clinical findings, laboratory findings, and identification of mutations in genes, such as FAS, that affect the process of apoptosis, or the programmed destruction of cells. Clinical findings that suggest ALPS include

  • Non ...
... More on Diagnosis of Autoimmune Lymphoproliferative Syndrome »

Genetics of Autoimmune Lymphoproliferative Syndrome

There are two types of FAS mutations:

  1. Germline mutations, which are present in all the body’s cells
  2. Somatic, or acquired, mutations, which are present only in select groups of cells

Although germline mutations are more common than somatic mutations ...7

... More on Genetics of Autoimmune Lymphoproliferative Syndrome »

Treatments: Autoimmune Lymphoproliferative Syndrome

Autoimmune Lymphoproliferative Syndrome (ALPS) Treatment: There currently is no standard cure for ALPS. The disorder can be managed by treating cytopenias and other autoimmune diseases that occur in people with ALPS, as well as monitoring for and treating lymphoproliferation, an ...8

... More Treatment Information for Autoimmune Lymphoproliferative Syndrome »

Research for Autoimmune Lymphoproliferative Syndrome

Why is the study of Autoimmune Lymphoproliferative Syndrome (ALPS) a priority for NIAID? ALPS can cause debilitating symptoms and put those affected at an increased risk of developing autoimmune diseases and lymphoma. Researchers at NIAID hope to develop safe and ...9

... More on Research for Autoimmune Lymphoproliferative Syndrome »

Names and Terminology

Other Names for This Condition

Source: GHR (NLM/NIH)10 ...

... More General Information on Autoimmune Lymphoproliferative Syndrome »

   •   •   •

References

  1. Source: NIAID (NIH): niaid.nih.gov/ topics/ alps/ Pages/ default.aspx
  2. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ autoimmune-lymphoproliferative-syndrome-alps
  3. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ study-diagnosis-treatment-rare-immune-disease
  4. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ autoimmune-lymphoproliferative-syndrome-causes
  5. Source: Algorithmically Generated List
  6. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ study-diagnosis-treatment-rare-immune-disease
  7. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ autoimmune-lymphoproliferative-syndrome-causes
  8. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ autoimmune-lymphoproliferative-syndrome-treatment
  9. Source: NIAID (NIH): niaid.nih.gov/ diseases-conditions/ autoimmune-lymphoproliferative-syndrome-alps
  10. Source: GHR (NLM/NIH): ghr.nlm.nih.gov/ condition/ autoimmune-lymphoproliferative-syndrome

   •   •   •

Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.