CANOMAD syndrome

Summary: CANOMAD syndrome is a rare chronic immune-mediated demyelinating polyneuropathy. CANOMAD stands for Chronic Ataxic Neuropathy Ophthalmoplegia IgM paraprotein Cold Agglutinins Disialosyl antibodies. Signs and symptoms of CANOMAD may include loss of muscle, tendon, and joint sensation, abnormal gait ...1

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Symptoms of CANOMAD syndrome

Symptoms: Willison et al. (2001) described the signs, symptoms, and laboratory findings of 18 people with CANOMAD syndrome. This is the largest case series reported to date. The most prominent symptom experienced by the patients was the loss of kinesthesia ...2

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Causes of CANOMAD syndrome

Cause: The underlying cause of CANOMAD syndrome is poorly understood. It appears as if IgM antibodies play a crucial role in the development of the disorder.[7] It also appears as if the condition is caused in some way by ...3

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Treatments: CANOMAD syndrome

Treatment: Oral or intravenous corticosteroids, -interferons, intravenous immunoglobulin (IVIG), plasma exchange, and cytotoxic drugs and a combination of these therapies have all been used in treating CANOMAD syndrome with varying success. Their use, however, has not been evaluated systematically.[1 ...4

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Names and Terminology

Other Names: Chronic Ataxic Neuropathy Ophthalmoplegia M-protein Agglutination Disialosyl antibodies syndrome; Chronic sensory ataxic neuropathy with anti-disialosyl antibodies ...Source: GARD (NIH)5 ...

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  1. Source: GARD (NIH): diseases/ 9778/ canomad-syndrome
  2. ibid.
  3. ibid.
  4. ibid.
  5. ibid.

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