Neuropathy is a general term for a disorder of the nerves. Neuropathy may affect many different nerve systems: peripheral neuropathy, autonomic neuropathy, digestive neuropathy, and other types. Neuropathy may result from nerve diseases, nerve entrapment disorders, metabolic disorders, alcoholism, nerve injury, vitamin deficiency, medication side-effect, and other causes. Neuropathy
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Symptoms of Neuropathy
Neuropathy can affect nerves throughout the body, causing numbness and sometimes pain in the hands, arms, feet, or legs, and problems with the digestive tract, heart, sex organs, and other body systems.
...Source: NIDDK (NIH)1
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Complications of Neuropathy
Complications of peripheral neuropathy
The outlook for peripheral neuropathy varies, depending on the underlying cause and which nerves have been damaged.
Some cases may improve with time if the underlying cause is treated, whereas in some people the damage may
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Causes of Neuropathy
Causes of peripheral neuropathy
In the UK, diabetes (both type 1 and type 2) is the most common cause of peripheral neuropathy.
Over time, the high blood sugar levels associated with diabetes can damage the nerves. This type of nerve damage
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Causes List for Neuropathy
Some possible causes of Neuropathy or similar disorders may include:4
- AIDS (forms of neuropathy, neuropathy, peripheral neuropathy)
- AL amyloidosis (Polyneuropathy, peripheral neuropathy)
- Abetalipoproteinemia (peripheral neuropathy)
- Acrodysostosis (Peripheral neuropathy)
- Acromicric dysplasia (Decreased nerve conduction velocity)
- Acroosteolysis dominant type ...
Types of Neuropathy
Classifying Hereditary Neuropathies:
Beginning with the pioneering work of Dyck and colleagues, CMT was separated into type 1 and type 2 (Shy et al., 2005). CMT1 is characterized by slowed conduction velocities in motor nerves (typically 10-40 m/s
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Diagnosis of Neuropathy
A number of tests may be used to diagnose peripheral neuropathy and its underlying cause.
When you see your GP, they'll ask about your symptoms and examine the affected area of your body. This may involve testing sensation
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Genetics of Neuropathy
Inherited Neuropathies Consortium (INC)
- Charcot Marie Tooth Disease (CMT) including CMT1, the dominantly inherited demyelinating neuropathies
- CMT2, the dominantly inherited axonal neuropathies
- CMT4, the recessively inherited neuropathies
Source: RDCRN (NCATS/NIH)7
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Risk Factors for Neuropathy
- regularly consume large amounts of alcohol
- are over 40 years old
Traditional painkillers such as paracetamol or ibuprofen aren't usually effective in treating neuropathic pain, so you may be prescribed a number of medications, such as amitriptyline, gabapentin or pregabalin.
...Source: NHS Choices UK9
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- Source: NIDDK (NIH): niddk.nih.gov/ health-information/ diabetes/ overview/ preventing-problems/ nerve-damage-diabetic-neuropathies
- Source: NHS Choices UK: nhs.uk/ conditions/ Peripheral-neuropathy/
- Source: Algorithmically Generated List
- Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ cms/ inc/ Healthcare-Professionals/ CMT
- Source: NHS Choices UK: nhs.uk/ conditions/ peripheral-neuropathy/ diagnosis/
- Source: RDCRN (NCATS/NIH): rarediseasesnetwork.org/ whoweare/ index.htm
- Source: NHS Choices UK: nhs.uk/ conditions/ peripheral-neuropathy/ causes/
- Source: NHS Choices UK: nhs.uk/ conditions/ ataxia/ treatment/
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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.