Symptoms of Poly-X Klinefelter syndrome
Symptoms of Poly-X KS [11]
Males with poly-X Klinefelter syndrome have more than one extra X chromosome, so their symptoms might be more pronounced than in males with KS. In childhood, they may also have seizures, crossed eyes, constipation, and recurrent ear infections. Poly-KS males might also show slight differences in other physical features.
Some common additional symptoms for several poly-X Klinefelter syndromes are listed below.
48,XXYY
- Long legs
- Little body hair
- Lower IQ, average of 60 to 80 (normal IQ is 90 to 110)
- Leg ulcers and other vascular disease symptoms
- Extreme shyness, but also sometimes aggression and impulsiveness
48,XXXY (or tetrasomy)
- Eyes set further apart
- Flat nose bridge
- Arm bones connected to each other in an unusual way
- Short
- Fifth (smallest) fingers curve inward (clinodactyly, pronounced KLAHY-noh-dak-tl-ee)
- Lower IQ, average 40 to 60
- Immature behavior
49,XXXXY (or pentasomy)
- Low IQ, usually between 20 and 60
- Small head
- Short
- Upward-slanted eyes
- Heart defects, such as when the chambers do not form properly12
- High feet arches
- Shy, but friendly
- Difficulty with changing routines
Source: NICHD (NIH)1
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Symptoms
Read more about symptoms of related disorders:
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References
- Source: NICHD (NIH): nichd.nih.gov/ health/ topics/ klinefelter/ conditioninfo/ Pages/ symptoms.aspx
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Note: This site is for informational purposes only and is not medical advice. See your doctor or other qualified medical professional for all your medical needs.